Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Antibiotic Selection00:57

Antibiotic Selection

59.3K
Overview
59.3K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

879
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
879
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.1K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.1K
Antimicrobial Proteins01:23

Antimicrobial Proteins

12.9K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
12.9K
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

6.7K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.7K
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

463
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
463

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Simulating interventions to prevent gastro-intestinal transmission of Clostridioides difficile and antimicrobial-resistant bacteria in healthcare settings: a model calibration study.

The Journal of hospital infection·2026
Same author

Molecular pharmacodynamics of amoxicillin-clavulanic acid for urinary tract infections caused by Escherichia coli.

Nature communications·2026
Same author

Prediction of antimicrobial minimum inhibitory concentration from bacterial genomes using a scalable and interpretable machine learning approach.

npj antimicrobials and resistance·2026
Same author

Impact of co-amoxiclav versus amoxicillin on the gastrointestinal microbiota in sub-Saharan children hospitalized with pneumonia.

npj antimicrobials and resistance·2026
Same author

Effectiveness of amoxicillin and amoxicillin-clavulanate for the treatment of community-acquired pneumonia in adults and children: a systematic review and meta-analysis.

BMJ open·2026
Same author

Using oral and parenteral formulation of AWaRe antibiotics as a proxy estimate of community and hospital healthcare sector use.

JAC-antimicrobial resistance·2026

相关实验视频

Updated: Jan 8, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.6K

抗菌剂的使用和耐药性.

Nada Reza1,2, Vineet Dubey1, Michael Sharland3

  • 1Department of Clinical Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.

BMJ (Clinical research ed.)
|December 12, 2025
PubMed
概括

抗菌素耐药性 (AMR) 威胁着医疗保健,促使全球采取政治行动. 虽然高收入国家在新技术方面取得了进展,但低收入国家却落后,这凸显了对抗耐药性感染的公平解决方案的需要.

更多相关视频

Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics
06:54

Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics

Published on: July 19, 2024

1.5K
Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
09:59

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Published on: July 21, 2023

1.7K

相关实验视频

Last Updated: Jan 8, 2026

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
08:58

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

7.6K
Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics
06:54

Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics

Published on: July 19, 2024

1.5K
Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
09:59

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Published on: July 21, 2023

1.7K

科学领域:

  • 全球健康 全球健康
  • 传染性疾病 传染性疾病
  • 公共卫生政策 公共卫生政策

背景情况:

  • 抗菌素耐药性 (AMR) 对医疗保健的安全性和有效性构成重大威胁.
  • 对抗药物耐药性的政治关注越来越大,全球承诺减少死亡率和改善抗生素使用情况证明了这一点.
  • 2024年联合国大会会议强调了解决AMR的紧迫性.

研究的目的:

  • 审查有关抗微生物药物耐药性的最近的政治行动和政策发展.
  • 确定新出现的威胁,并评估针对耐药病原体的可用和新型抗生素.
  • 分析AMR管理的全球格局,强调高收入国家与低收入和中等收入国家之间的差异.

主要方法:

  • 对最近的政治行动和政策优先级的文献综述.
  • 评估当前和新兴的抗菌剂.
  • 对抗药物耐药性挑战和解决方案的全球分布的分析.

主要成果:

  • 全球对抗抗菌药物耐药性的方法仍然不平衡,在诊断,管理和感染控制方面存在显著的差异.
  • 高收入国家正在利用人工智能等先进技术来进行抗菌药物抵抗管理.
  • 低收入和中等收入国家对这些进展的获取有限,这影响了它们对抗耐药性感染的能力.

结论:

  • 尽管政治参与度增加,但公平获得抗菌药物耐药性解决方案仍然是一个关键挑战.
  • 通过有针对性的预防和最佳治疗来保持基本抗生素的疗效,对于全球有效的医疗保健至关重要.
  • 解决AMR策略的全球不平衡对于减轻未来威胁和确保全球安全的医疗保健提供至关重要.