相关实验视频

Updated: Jan 8, 2026

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

在乳头细胞癌中PABPC1的表达及其对生存结果的意义

Cheng Huang¹, Aichun Long², Tianyun Li¹

¹Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.

Journal, genetic engineering & biotechnology

|December 12, 2025

概括

聚A结合蛋白细胞质蛋白1 (PABPC1) 在乳头脏细胞癌 (pRCC) 中升高. 高PABPC1表达与较差的患者存活率相关,表明其作为预后生物标志物的潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物发现发现

背景情况:

乳头细胞癌 (pRCC) 是癌的一个重要亚型.
确定可靠的预后生物标志物对于改善pRCC患者的治疗结果至关重要.
在pRCC进展中,聚A结合蛋白细胞质蛋白1 (PABPC1) 的作用尚不清楚.

研究的目的:

为了研究PABPC1在pRCC中的表达模式.
评估PABPC1在pRCC中的预后相关性.
评估PABPC1作为pRCC的潜在临床结果生物标志物.

主要方法:

使用 GSCALite 和 UALCAN 数据库对 pRCC 瘤 (n=290) 与正常组织 (n=32) 的 PABPC1 mRNA 表达的分析.
生存分析 (OS,PFS,DSS,DFI) 相关联PABPC1表达水平与患者的结局.
与临床和病理阶段相关的PABPC1表达的检查.
在临床样本上使用HE和IHC染色的验证.

主要成果:

与正常组织相比,PABPC1表达在pRCC组织中显著上调.
高PABPC1表达与降低整体存活率,无进展存活率,疾病特异性存活率和无疾病间隔密切相关.
在pRCC中,PABPC1mRNA水平随着临床和病理阶段的进展而增加.
免疫检查点 (PD1/PDL1) 抑制剂治疗可以改善高PABPC1.1的pRCC患者的预后.

结论:

PABPC1是一种潜在的预后生物标志物,用于乳头脏细胞癌 (KIRP).
增加PABPC1表达意味着KIRP患者的预后较差.
针对免疫检查点可能有利于KIRP患者高PABPC1.

关键词:

生物标志物生物标志物免疫检查点分析分析一个 PABPC1 的人.在PD-1中使用PD-1.状细胞癌是状细胞癌.

更多相关视频

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

Immunohistochemical Staining of B7-H1 PD-L1 on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue

Immunohistochemical Staining of B7-H1 PD-L1 on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue

Published on: January 3, 2013

相关概念视频

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...