设计生物学和心身健康
Katsuyoshi Kumagai1, Ayumi Chiba2, Hiroaki Yajima3
1Department of Health Sciences of Mind and Body, Faculty of Human Sciences, University of Human Arts and Sciences, Saitama, Japan; Graduate School of University of Human Arts and Sciences, Saitama, Japan.
Journal, genetic engineering & biotechnology
|December 12, 2025
概括
人工细胞和人工智能等设计生物学创新正在彻底改变健康科学,通过将分子工程与整体福祉相结合,为压力,情绪健康和代谢障碍提供预测策略.
科学领域:
- 设计生物学设计生物学
- 心灵和身体的健康科学 (HS-MB)
背景情况:
- 心理和社会因素显著影响生理系统,如神经内分泌,自主,免疫,代谢和睡眠循环系统.
- 传统的健康科学往往依赖于观察方法,限制了预测和设计导向的干预.
研究的目的:
- 探索设计生物学进步如何改变HS-MB.
- 突出新技术在调节压力,情绪健康,免疫平衡和生活方式障碍方面的潜力.
主要方法:
- 利用人工细胞来建模信号通路和相互作用.
- 采用DNA纳米结构和原木为可编程纳米载体.
- 利用下一代基因组编辑 (主要,基础,表观基因组编辑) 用干细胞和有机体模型.
- 将人工智能 (AI) 集成到自动化设计-构建-测试-学习 (DBTL) 周期的生物基础设施中.
主要成果:
- 人工细胞为神经递质信号传递,免疫相互作用和肠-大脑通信提供可控制的模型.
- 先进的基因组编辑可以精确调制精神病风险基因.
- 人工智能驱动的生物发明加速了分子发现和优化.
- 这些技术促进了健康管理的预测和设计导向策略.
结论:
- 设计生物学为21世纪医学提供了基础框架,将分子工程与整体福祉相结合.
- 设计生物学与HS-MB的战略协调对于未来的医学进步至关重要.
- 伦理和监管方面的考虑是这些技术的开发和应用的组成部分.
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