多器官外围T细胞淋巴瘤呈现为孤立心肌病
Abdullah A Memon1, Eric Darrah2, Ty Monty3
1Division of Head and Neck Surgical Oncology and Reconstruction, Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
JACC. Case reports
|December 12, 2025
概括
周围T细胞淋巴瘤,未另有说明 (PTCL-NOS) 可以呈现为心肌病,没有扩大的淋巴结. 早期心内膜组织活检对于诊断这种罕见的,侵略性的恶性瘤至关重要.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 病理学 病理学 病理学
背景情况:
- 周围T细胞淋巴瘤,未另有说明 (PTCL-NOS) 是一种侵略性的非霍奇金淋巴瘤.
- 外节干扰是常见的,但没有淋巴腺病的广泛透是罕见的.
研究的目的:
- 为了呈现一种罕见的心脏主导性PTCL-NOS与多器官透的罕见病例.
- 突出诊断挑战和内肌心活检在不明原因心肌病的重要性.
主要方法:
- 一个69岁的男性患有渐进性心肌病的病例报告.
- 内心肌活检显示了非典型的T细胞透.
- 尸体解剖证实了多个器官的扩散T细胞透.
主要成果:
- 由于缺乏系统性症状和不确定的初始检查,PTCL-NOS的诊断被推迟.
- 尸检显示有大量的心脏,脏和上腺透.
- 免疫组织化学对淋巴瘤怀疑,但生命期间缺乏明确的克隆标志物.
结论:
- 心脏主导的PTCL-NOS可以在没有淋巴腺病变的情况下出现.
- 内心肌瘤活检对于诊断无法解释的心肌病症至关重要,即使没有明显的恶性瘤迹象.
- 在无法解释的心脏功能障碍的情况下,对恶性瘤的早期考虑至关重要.
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