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可NIR激活的多米诺级联催化纳米酶反应器用于膀癌多机制协同免疫疗法

Yongnan Jiang¹, Qingling Zhang², Yuhan Zhang¹

¹Department of Urology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|December 12, 2025

概括

这项研究引入了一种具有纳米酶的新型热反应性水凝,用于膀癌症治疗. 它增强药物输送,诱导瘤细胞死亡,并刺激免疫反应,以改善局部治疗.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
在瘤学瘤学.

背景情况:

膀癌的静脉内疗法在组织透和有效性方面面临挑战.
目前的治疗方法往往会导致非目标效应和有限的治疗结果.

研究的目的:

开发一种热响应的水凝系统,用于增强膀癌治疗.
整合纳米酶和酶以获得协同治疗效果和改善药物输送.

主要方法:

一种热反应性水凝 (PNH) 的设计,该水凝封装了酸盐涂层的Fe/Mn双金属纳米酶 (FMCC) 和胆固醇氧化酶 (ChOx).
利用FMCC的过氧化酶,酶和谷氨氧化酶活动与ChOx一起,以增强反应性氧物种 (ROS) 生产并诱导铁亡.
使用近红外 (NIR) 辐射来控制药物释放和轻度光热疗法 (MPTT).

主要成果:

该CS涂层改善了粘膜粘附性和组织透性,以便更好地进行静脉内输送.
尼尔射线照射触发了水凝液化,用于空间时间控制释放和MPTT.
该系统展示了光热疗法,铁诱导和免疫调节的协同效应,包括M1巨分极和cGAS-STING通路激活.

结论:

开发的纳米酶-水凝系统为局部膀癌治疗提供了改善的组织透,代谢干扰和免疫刺激.
这种综合方法有望克服当前静脉内疗法的局限性.
MPTT,铁和免疫激活的结合为有效的膀癌管理提供了一个新的策略.

关键词:

热反应性水凝的热反应性水凝.铁性化 (ferroptosis) 是一种免疫透免疫透是什么?通过静脉内灌注.纳米酶纳米酶是一种纳米酶.

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