揭示全球多样性的病菌和与宿主微生物的功能互动
Yanhan Ji1, Xu Liu1, Shuai Zhao2
1Key Laboratory of Agricultural and Environmental Microbiology, Ministry of Agriculture and Rural Affairs, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu, 210014, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|December 12, 2025
概括
候选细胞辐射 (CPR),或Patescibacteriota,是微小的细菌,全球分布不明. 这项研究揭示了它们在通过互补功能支持宿主新陈代谢中的多样性作用,突出了它们的生态意义.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 生态生态学 生态生态学
背景情况:
- 病性细菌 (Candidate Phyla Radiation,CPR) 是一种具有生生活方式的无处不在的超小细菌.
- 它们的全球分布和与宿主的功能相互作用在很大程度上是未知的.
- 了解CPR的生态作用对于微生物网络动态至关重要.
研究的目的:
- 为了确定Patescibacteriota的全球分布和分类学多样性.
- 研究Patescibacteriota和宿主相关细菌之间的功能相互作用和代谢协同作用.
- 在元基因组数据中确定可靠的家族遗传标记,用于CPR检测.
主要方法:
- 利用了全面的Patescibacteriota基因组资源和全球多息地元基因组数据集.
- 采用核糖体蛋白S3 (rpS3) 作为从短读元基因组中准确恢复多样性的遗传学标记.
- 进行了网络分析和全基因组功能查,以发现共发生模式和代谢相互作用.
主要成果:
- 在八个不同的生态系统中确定了Patescibacteriota的广泛的分类学多样性和显著的社区异质性.
- 揭示了Patescibacteriota与其他细菌之间的息地特定的共发生模式,表明了潜在的功能协同作用.
- 发现了Patescibacteriota编码的酶 (NirK,NorB),可以减轻来自酸盐和氧化的宿主压力.
结论:
- 细菌群具有被低估的多样性,并通过互补的生化功能在支持宿主代谢方面发挥着至关重要的作用.
- 这项研究为全球生态系统中Patescibacteriota的生态意义和进化适应提供了新的见解.
- rpS3被证实是从元基因组数据中恢复CPR多样性的可靠标志物.
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