症状在60分钟间隔出现的时间 儿童口服饮食挑战
Nana Kojima1, Makoto Nishino1, Ken-Ichi Nagakura1
1Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.
概括
对于口服食品挑战 (OFCs),剂量之间的较长间隔对于安全至关重要. 这项研究发现,症状发病时间,即使是60分钟的间隔,表明需要剂量之间>30分钟.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 儿科胃肠病学 儿科胃肠病学
- 临床营养学 临床营养学
背景情况:
- 口服食物挑战 (OFC) 对于诊断食物过敏和评估耐受性至关重要.
- 确定最佳的剂量间隔对于OFC的安全性和准确性至关重要,但尚未确立.
- 这项研究解决了对儿科OFC症状发病时间的清晰度的需求.
研究的目的:
- 为了研究低剂量口服食品挑战 (OFCs) 中症状发病时间,使用60分钟的间隔.
- 评估儿童患者OFC剂量间隔的安全性和准确性.
- 为了为常见的食物过敏原提供最佳的OFC协议.
主要方法:
- 低剂量OFC在对蛋,牛奶,小麦和花生过敏的儿童中的回顾性分析.
- 在60分钟的间隔内给予两剂.
- 记录了症状发病时间,在观察客观症状时,OFCs被认为是积极的.
主要成果:
- 在1610名儿童中,有552人 (34%) 在四种过敏原中呈阳性OFC.
- 症状发作的中位数时间在第一剂后25-45分钟,第二剂后25-35分钟之间.
- 在64%的第一剂和54%的第二剂中观察到晚发反应 (≥30分钟).
结论:
- 剂量间隔超过30分钟对于安全和准确的口服食品挑战至关重要.
- 这些发现支持需要延长时间间隔来捕捉潜在的晚发反应.
- 目前低剂量OFC的60分钟间隔强调了剂量之间足够的间隔的重要性.
更多相关视频
08:52Psychophysical Tracking Method to Assess Taste Detection Thresholds in Children, Adolescents, and Adults: The Taste Detection Threshold TDT Test
Published on: April 21, 2021
5.3K
09:17Psychophysical Tracking Method to Measure Taste Preferences in Children and Adults
Published on: July 16, 2016
18.1K
相关概念视频
01:20Taste Buds and Receptors
4.5K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
4.5K
01:17Assessment of the Gastrointestinal System I: Subjective Data
594
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
594
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
229
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
229