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Updated: May 6, 2026

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蛋白质组范围内的孟德尔随机化意味着共享的死-死效应在多发性硬化症易感性的因果途径

Wu Yan1, Wang Jianhong1,2, Jiang Wen1

  • 1Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.

Annals of the New York Academy of Sciences
|December 12, 2025
PubMed
概括

这项研究证实铁亡和亡途径是导致多发性硬化症 (MS) 风险的原因. 关键蛋白质如IFNA4和TNFAIP3,以及调节剂如APOE,被确定为MS的潜在治疗标.

关键词:
在 IFNA4 中,IFNA4 是门德尔的随机化在TNFAIP3中使用.陶塑料是一种陶塑料.铁性化 (ferroptosis) 是一种多发性硬化症多发性硬化症尸体的死亡和死亡.

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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