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Updated: Jan 8, 2026

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DNA甲基化预测了冠状动脉疾病的不良结果

Min Qin^1,2,3,4,5,6, Xiaoxue Tian^1,2,7, Qili Wu^1,2

¹Department of Pharmacy, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Nature communications

|December 12, 2025

概括

血液中的DNA甲基化标记可以预测冠状动脉疾病 (CAD) 患者的未来死亡. 这些表观遗传标记为预后和心血管疾病的潜在临床应用提供了宝贵的见解.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
心血管研究研究心血管研究
基因组学就是基因组学.

背景情况:

冠状动脉疾病 (CAD) 是全球主要的死亡原因.
心肌梗塞 (MI) 和中风等不良结果是CAD的重要并发症.
预测性生物标志物用于CAD预后对于及时干预至关重要.

研究的目的:

确定与CAD患者未来死亡率相关的DNA甲基化标志物.
研究这些标记物与临床和生物因素的相关性.
使用DNA甲基化数据开发和验证CAD的预后模型.

主要方法:

从933名中国CAD患者的血白细胞中分析DNA甲基化.
利用来自三个中心的长达13年的随访数据.
与临床结果,炎症,心脏功能和基因表达相关联的差异甲基化部位 (DMPs).

主要成果:

确定了70个与CAD患者未来死亡相关的DMP.
这些DMP与炎症,左心室功能和高密度胆固醇相关.
发现FKBP5是一种由特定甲基化位点调节的关键基因,其上调与心脏病发作和中风有关.
结合10个甲基化位点和5个临床特征的预后模型显示,与传统模型相比,其性能优越.

结论:

血液中的DNA甲基化模式作为CAD预后的有价值的预测因素.
表观遗传标记物,如调节FKBP5的标记物,在CAD进展和不良事件中发挥作用.
开发的预后模型具有改善CAD患者管理的临床转化潜力.

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