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Updated: Jan 8, 2026

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对GM4951作为脂质滴滴GTPase调节肝脂质代谢的结构洞察

Rishi Raj1, Yiao Jiang2, Rahul Kumar Jha3

  • 1Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA. Rishi.Raj@UTSouthwestern.edu.

Nature communications
|December 12, 2025
PubMed
概括

GM4951是一种与免疫相关的GTPase,可以抵消肝脏脂肪的积累. 它的结构和突变揭示了脂质滴滴定位和与HSD17B13相互作用的独特机制,使其与其他IRG区分开来.

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