通过IL-17介导的抗真菌免疫力限制了Candida albicans在口腔中的病原性
Ricardo Fróis-Martins1,2, Kontxi Martinez de San Vicente1,2, Corinne Maufrais3,4
1Section of Immunology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.
Nature microbiology
|December 12, 2025
概括
介质素-17 (IL-17) 信号传递防止常见的 Candida albicans 变得致病. 免疫功能障碍允许真菌适应并引起疾病,突出IL-17.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 菌类学 菌类学是指菌类学.
背景情况:
- 菌是一种共生真菌,当宿主免疫防御受到损害时,可以引起机会性感染.
- 粘膜皮肤候群病常常在患有互白素-17 (IL-17) 免疫缺陷的个体中观察到,这表明IL-17在真菌控制中起着关键作用.
研究的目的:
- 调查IL-17信号传递在口腔殖民期间保持Candida albicans在非致病状态中的作用.
- 了解IL-17缺乏如何影响真菌基因表达,宿主组织反应和真菌适应.
主要方法:
- 使用了口腔Candida albicans殖民的小鼠模型.
- 分析了与真菌病原性和宿主免疫反应相关的基因表达特征.
- 评估了上皮质屏障完整性和炎症标志物.
- 研究了化机制和calprotectin表达.
主要成果:
- 在C. albicans中,IL-17信号的丧失诱导了真菌线索和高调的相关基因.
- 缺少IL-17导致了上皮屏障的破坏,炎症和异常的IL-22和IL-13产生.
- 由于减少了calprotectin表达,对IL-17缺乏的小鼠观察到化功能受损.
- 长期免疫失调被选择为稳定,致病性C. albicans变体,反映临床隔离物.
结论:
- IL-17信号传递对于保持Candida albicans在非致病状态和防止宿主组织损伤至关重要.
- 免疫功能障碍,特别是IL-17缺乏,促进C. albicans的适应,多样化和致病性.
- 这些发现阐明了IL-17对真菌感染的保护机制以及C. albicans在不受调节的免疫环境中的进化动态.
相关概念视频
01:24T Cell Types and Functions
2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
01:28Fungal Phylum Microsporidia
382
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
382