急性压力会导致表观基因组范围内的DNA甲基化发生变化
Lea Zillich1, Nathaly S Czernin1, Oscar Crespo Salvador1
1Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
概括
急性压力会动态改变DNA甲基化 (DNAm) 模式,影响皮质醇的反应性,并影响甲状腺功能和认知中的基因. 这项研究揭示了暴露于压力后的动态表观遗传变化.
科学领域:
- 神经科学是一个神经科学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 内分泌学 在内分泌学.
背景情况:
- 压力显著影响精神和体质健康,因为它破坏了下丘脑-垂体-上腺 (HPA) 轴.
- 人们假设表观遗传机制,特别是DNA甲基化 (DNAm),可以调解压力和健康结果之间的联系.
- 急性压力对DNAm的纵向影响仍然在很大程度上未被探索.
研究的目的:
- 为了研究急性压力,皮质醇反应性和DNA甲基化中的动态变化之间的关系.
- 识别特定的DNA甲基化模式和与应激反应相关的基因.
主要方法:
- 122名健康人接受了马斯特里赫特急性压力测试 (MAST).
- 唾液皮质醇在七个时间点测量;血液被收集用于DNA甲基化分析前后的压力.
- 统计分析包括强大的线性模型来预测皮质醇反应性和混合线性模型用于纵向DNAm变化.
主要成果:
- 基线DNA甲基化预测了皮质醇反应性,确定了120个CpG位点和四个差异甲基化区域 (DMR).
- 纵向表观基因组全方位分析显示,在压力后的32个CpG位点和4个DMR处发生了动态DNAm变化.
- 基因 Ontology 分析突出了与学习,认知和突触过程相关的术语,其中 TTR 和 TSHR 基因被确定为关键命中.
结论:
- 急性压力与DNA甲基化中的动态变化有关,这些变化与皮质醇反应性有关.
- 参与甲状腺功能和转录调节的关键基因也与急性应激反应有关.
- 需要进一步的多学科研究来验证这些发现并探索它们的功能意义.
更多相关视频
相关概念视频
01:37Epigenetic Regulation
3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.7K
01:46Epigenetic Regulation
33.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.4K
01:27Introduction to Stress and Lifestyle
491
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
491
01:24Physiological Foundation of Stress
512
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
512
01:37Hypothalamic-Pituitary Axis
65.3K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
65.3K
01:19Psychoneuroimmunology: Diabetes and Cancer
409
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
409