一种含有Limosilactobacillus reuteri和GOS的幼儿配方调节肠道微生物组,增强骨和肌肉发育:一项随机试验
Nicolas Bonnet1, Maria Rosario Capeding2, Léa Siegwald1
1Nestlé Institute of Health Sciences, Nestlé Research, Vers-Chez-Les-Blanc & EPFL innovation Park, Lausanne, Switzerland.
Nature communications
|December 12, 2025
概括
一种含有Limosilactobacillus reuteri和galacto-oligosaccharides的新幼儿配方改善了幼儿的骨和肌肉发育. 这种配方还积极改变了肠道微生物群的组成和功能.
科学领域:
- 儿童营养学 儿童营养学
- 微生物组研究 微生物组研究
- 肌肉骨健康 肌肉骨健康
背景情况:
- 幼儿时期是肌肉骨发育的关键时期.
- 肠道微生物群的组成影响全身健康,包括骨和肌肉.
- 协生菌,结合益生菌和益生菌,显示出调节肠道微生物群和改善健康结果的潜力.
研究的目的:
- 评估一种含有Limosilactobacillus reuteri DSM 17938和银-寡糖化合物 (GOS) 的实验性幼儿配方 (EYCF) 对菲律宾幼儿的肌肉骨发育的影响.
- 评估EYCF对肠道微生物群组成和功能的影响.
- 探索肠道微生物群变化与肌肉骨结果之间的关系.
主要方法:
- 一个为期6个月的随机,双盲受控试验,涉及182名2至3岁的菲律宾儿童.
- 参与者接受了EYCF (L. reuteri + GOS) 或对照牛奶 (CM).
- 结果包括骨的声音速度,肌肉强度,维生素D水平,骨循环标记物,肠道微生物群和便代谢物.
主要成果:
- 与CM相比,食用EYCF的儿童在3个月和6个月时明显增加了部的声音速度.
- 消费EYCF改变了肠道微生物组合,增加了L. reuteri和Bifidobacteria的丰富性.
- 增加L. reuteri的丰度与改善的骨质和肌肉强度相关.
结论:
- 含有L. reuteri和GOS共生菌的EYCF的消费增强了幼儿的肌肉骨发育.
- 这些改善是通过调节肠道微生物群的组成和功能来实现的,突出显示了肠-肌肉-骨交叉.
- 这项研究提供了关于协生菌在生命早期发育中的作用的宝贵见解.
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