对人类皮肤的非侵入性评估的表观遗传年龄预测因子
Angel Menendez Vazquez1, Dimitris Katsanos1, Miruna Vasile1
1Mitra Bio, Translation and Innovation Hub, London, UK.
npj aging
|December 12, 2025
概括
新的DNA甲基化钟,MitraSolo和MitraCluster,通过面部带精确测量皮肤的生物年龄. 这些非侵入性表观遗传钟显示出高精度和可重复性,用于衰老研究和护肤创新.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 皮肤病学 皮肤病学
- 衰老研究研究 衰老研究
背景情况:
- 皮肤老化在视觉上是明显的,并且受到环境因素的影响.
- DNA甲基化钟是可靠的衰老生物标志物,但传统上需要侵入性样本或有限的微阵列数据.
- 现有的方法在皮肤衰老评估的准确性和可扩展性方面存在局限性.
研究的目的:
- 开发精确且非侵入性的表观遗传钟,用于测量皮肤的生物年龄.
- 为了使用大规模的表皮甲基测序数据验证这些时钟.
- 通过各种条件和干预来评估时钟的性能.
主要方法:
- 开发了两种新型的DNA甲基化钟 (MitraSolo和MitraCluster),在大量人类表皮甲基测序数据 (n=462) 的数据集上进行训练.
- 采用非侵入性面部带剥离用于采样.
- 在独立,纵向和外部数据集上验证模型,将它们与已建立的时钟进行比较.
主要成果:
- 实现了皮肤生物年龄的准确预测,误差约为4年,超过现有的表皮钟.
- 即使在较低的测序深度下,也证明了高精度,确保了具有成本效益的可扩展性.
- 显示高可重现性与2年以下的个体内预测变化和跨地点和方法的概括预测能力.
结论:
- 米特拉Solo和米特拉Cluster是为人类皮肤优化的表观遗传时钟,提供准确的,非侵入性的老化评估.
- 这些时钟适用于临床研究,监测干预措施和推进护肤创新.
- 非侵入性和可扩展性支持在衰老研究和个性化皮肤病学中的广泛应用.
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