在模拟微重力条件下,PI3K/AKT/mTOR通路和c-Myc抑制肝细胞悬浮
Yue Xiong1, Chiyuan Ma1, Jingtong Xie1
1Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
NPJ microgravity
|December 12, 2025
概括
模拟微重力 (SMG) 导致肝细胞形成球形. 悬浮细胞进入休眠状态,而附着细胞则受到PI3K/AKT/mTOR通路和c-Myc.的保护.
科学领域:
- 细胞生物学 细胞生物学
- 太空生物学空间生物学
- 肝细胞研究研究 肝细胞研究
背景情况:
- 微重力影响细胞生长和细胞亡.
- 以前的研究表明,模拟微重力 (SMG) 抑制了肝细胞的增殖,并诱导了亡.
研究的目的:
- 在SMG下调查肝细胞的行为.
- 阐明细胞悬浮和休眠背后的机制.
主要方法:
- 使用随机定位机来进行SMG模拟.
- 在体外培养肝细胞.
- 分析了细胞增殖,细胞亡和球形形成.
- 研究的PI3K/AKT/mTOR通路和c-Myc表达.
主要成果:
- SMG诱导的肝细胞悬浮,形成球形.
- 悬浮的细胞显示生长减少和亡,表明休眠状态.
- 附着的细胞显示上调PI3K/AKT/mTOR通路和c-Myc.
- 在SMG下c-Myc操纵受影响细胞悬浮.
结论:
- PI3K/AKT/mTOR通路和c-Myc保护肝细胞免受SMG诱导的休眠状态.
- 在SMG下肝细胞悬浮是一种涉及特定分子通路的生存机制.
更多相关视频
08:50In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines
Published on: April 18, 2025
849
11:06Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
5.2K
相关概念视频
PI3K/mTOR/AKT Signaling Pathway
5.3K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
5.3K
mTOR Signaling and Cancer Progression
4.6K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.6K
