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揭示苏丹境内流离失所人口中的E型肝炎病毒多样性:分子流行病学方法

Hytham A Osman^1,2, Wafaa M K Bakr¹, Mona H Hashish¹

¹Department of Microbiology, High Institute of Public Health, Alexandria University, Alexandria, 21561, Egypt.

Tropical medicine and health

|December 12, 2025

概括

肝炎E病毒 (HEV) 基因型1e在苏丹境内流离失所者 (IDP) 中被发现. 这一发现凸显了撒哈拉以南非洲地区HEV-1e的区域传播以及持续监测的必要性.

科学领域:

* 病毒学病毒学
* 流行病学流行病学
* * 公共卫生公共卫生

背景情况:

* 肝炎E病毒 (HEV) 是急性病毒性肝炎的重要原因,特别是在资源有限和人道主义环境中.
*国内流离失所者 (IDPs) 面临着由于卫生条件不佳和水源受污染的高风险.
*了解像境内流离失所者这样的弱势群体中的HEV负担和分子流行病学对于有效的公共卫生干预至关重要.

研究的目的:

* 在苏丹蓝尼罗州阿尔-阿扎扎营地内流离失所者 (IDPs) 中描述E型肝炎病毒 (HEV) 的分子流行病学和基因型.
* 确定HEV感染的流行率,并确定在这个特定的国内流离失所人口中循环的HEV基因型.

主要方法:

* 一项涉及1078名参与者的跨部分研究于2021年8月至12月进行.
* 血清样本被选为抗HEVIgM和IgG抗体.
*实时RT-PCR和ORF2区域的测序在18个高质量的RNA阳性样本上进行了基因定型和遗传学分析.

主要成果:

*观察到HEV IgG抗体的高血清流行率,75.6%的参与者测试阳性.
*所有18个测序的HEV分离物被确定为基因型1,亚型1e (HEV-1e),与帕斯拉赫佩病毒密切相关.
* 遗传学分析显示,苏丹的HEV-1e分离物与来自得和尼日利亚的菌株聚集在一起,表明在撒哈拉以南非洲的区域循环.

结论:

*该研究证实了苏丹境内流离失所人口中HEV基因型1e的传播,与撒哈拉以南非洲地区的区域模式一致.
* 调查结果强调了在国内流离失所者环境中持续HEV监测的重要性.
* 跨境传播HEV-1e的可能性需要在公共卫生战略中考虑.

关键词:

基因型定制是指基因型定制.这是一种HEV-1e病毒.肝炎E病毒的感染.国内流离失所者国内流离失所者人类遗传学分析苏丹苏丹苏丹苏丹

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