相关实验视频
Updated: Jan 8, 2026

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
2.4K
乌斯特基努马布可能对自身免疫性甲状腺疾病有治疗作用
Suleyman Sami Guzel1, Ahmet Numan Demir2, Tugce Eskazan3
1Department of Internal Medicine, Istanbul University-Cerrahpasa, Fath, Istanbul, 34098, Turkey.
Scientific reports
|December 12, 2025
概括
乌斯特基努马布,向英特鲁金 (IL) -12 / 23,可能会在炎症性肠病 (IBD) 患者中保护甲状腺功能. 与其他治疗方法相比,这种生物药物显示出自身免疫性甲状腺疾病 (AITD) 的发病率较低,甲状腺结构更好.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
背景情况:
- 介质蛋白 (IL-12) 和IL-23是自身免疫的关键驱动因素,与自身免疫性甲状腺疾病 (AITD) 有关.
- 炎症性肠病 (IBD) 患者经常表现出甲状腺功能障碍和更高的AITD流行率.
- 针对IL-12/23的生物疗法用于IBD,具有潜在的全身影响.
研究的目的:
- 评估一种IL-12/23抑制剂乌斯特基努马布 (ustekinumab) 对IBD患者AITD的影响.
- 在接受不同生物药物治疗的IBD患者中比较甲状腺健康状况.
- 评估乌斯特基努马布对甲状腺自身免疫的潜在保护作用.
主要方法:
- 对203名IBD患者和58名健康对照者的横截面研究.
- 综合性甲状腺检查,包括生物化学测试和甲状腺超声波.
- 基于生物治疗 (ustekinumab,infliximab,adalimumab) 和对照组的AITD发病率和甲状腺结构的分析.
主要成果:
- IBD患者的AITD发病率和甲状腺结构受损程度高于对照组.
- 接受生物治疗的IBD患者的AITD发病率较低,甲状腺结构比非生物治疗者更好.
- 与infliximab和adalimumab组相比,ustekinumab组表现出AITD发病率最低,抗甲状腺过氧化酶水平降低,超声波检测结果优异.
结论:
- 在IBD患者中,生物疗法,特别是ustekinumab,可能为甲状腺健康提供保护性或治疗性益处.
- 乌斯特基努马布证明了作为AITD和IBD同时存在的患者的治疗选择的潜力.
- 准IL-12/23通路可能是缓解慢性炎症疾病中甲状腺自身免疫力的策略.
相关概念视频
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
445
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
445
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
459
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
459
Myasthenia Gravis: Overview and Treatment
2.7K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.7K
Synthesis and Regulation of Thyroid Hormones
7.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.1K
Functions of Thyroid Hormones
4.9K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
4.9K
Autoimmune Disorders
1.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.4K

