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Updated: Jan 8, 2026

Monitoring Leucine-Rich Repeat Containing 8 Channel (LRRC8/VRAC) Activity Using Sensitized-Emission Förster Resonance Energy Transfer (SE-FRET)
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LRRC8A:D体积调节的离子通道的组装和脂质关口

Antony Lurie1,2, Christina A Stephens3, David M Kern1,2,4

  • 1Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.

Nature communications
|December 12, 2025
PubMed
概括

体积调节的离子通道 (VRACs) 与不同的子单元组合在一起,影响它们的特性. 新的冷-EM结构揭示了LRRC8D子单元如何改变VRAC,并显示毛孔脂质如何进入这些必需的离子通道.

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