长期的COVID涉及到促炎和免疫疲劳路径的激活
Malika Aid1, Valentin Boero-Teyssier1, Katherine McMahan1
1Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Nature immunology
|December 13, 2025
概括
长期的COVID与持续的免疫激活和感染后180天的炎症有关. 这些慢性炎症途径可能为长期COVID (LC) 提供新的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 基因组学就是基因组学.
- 蛋白质组学是指蛋白质组学.
背景情况:
- 长期COVID (LC) 在SARS-CoV-2感染后呈现出各种慢性症状.
- 对于LC病变的假设包括持续的病毒,自身免疫和免疫功能障碍.
- 了解LC的潜在机制对于开发有效的治疗方法至关重要.
研究的目的:
- 调查长期COVID患者的免疫学,病毒学,转录基因和蛋白质基因个人资料.
- 与康复个人相比,识别与长期COVID相关的持久生物变化.
主要方法:
- 在两个独立的队列中进行了多原子分析 (免疫学,病毒学,转录组,蛋白质组).
- 参与者包括未感染的对照组,急性感染的个体,康复的对照组和长期COVID患者.
- 纵向数据收集跨越了2020-2021年和2023-2024年的时间.
主要成果:
- 长期COVID患者在感染后180天后表现出持续的免疫激活和炎症反应.
- 在LC中升级调节的途径包括JAK-STAT,互白素-6,补充剂,新陈代谢和T细胞耗尽.
- 在两个队列中一致的发现加强了长期COVID持续炎症的证据.
结论:
- 长期COVID的特点是慢性炎症通路的持续激活.
- 这些发现表明长期COVID的潜在治疗点.
- 确定这些途径可能会导致开发用于疾病诊断和监测的新生物标志物.
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