基因型特定的人类乳头瘤病毒模式及其在整个宫癌谱中的影响:来自西印度的横截面研究
Madhvi Manisha1, Pratibha Singh1, Garima Yadav1
1Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
概括
人类乳头瘤病毒 (HPV) 检测是宫癌查的关键. 在高风险病变中,HPV 16,18,31,33和45最常见,这表明印度需要有针对性的疫苗接种和查策略.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 宫癌查严重依赖于人类乳头瘤病毒 (HPV) 检测.
- 了解HPV基因型分布对于有效的查和预防策略至关重要.
研究的目的:
- 为了确定HPV基因型在女性的患病率,查结果呈阳性,并通过他的病理学证实了高风险的宫病变.
- 为了将HPV基因型阳性与子宫病变的严重程度相关联.
主要方法:
- 宫癌查对25至65岁的女性进行了查.
- 查阳性女性接受了HPV检测,肠镜检查和活检以确认其组织病理学.
- 对检测到的HPV菌株进行了基因定型.
主要成果:
- 在56.8%的查阳性女性中检测到HPV,HPV16是最常见的基因型 (38.1%).
- 在活检证明的高度状内皮病变 (HSIL) 或更严重的女性中,HPV 16 (78%),HPV 18 (14%) 和HPV 33 (12%) 是最常见的.
- 在HPV基因型阳性和HSIL+病变的存在之间观察到强烈的相关性 (φ = 0.7;P < 0.001).
- 16,18,31,33,和45型的HPV基因型与高度和侵入性宫病变有显著的相关性.
结论:
- 在显著的宫病变中,HPV 16,18,31,33和45占主导地位.
- 建议针对性查和疫苗接种策略,重点关注这些高风险的HPV类型,以减少印度人口中与HPV相关的宫疾病的负担.
相关概念视频
Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
Mechanisms of Retrovirus-induced Cancers
6.8K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
6.8K
Single Nucleotide Polymorphisms-SNPs
17.8K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.8K
Cancers Originate from Somatic Mutations in a Single Cell
14.5K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
14.5K
Cancer Vaccines
929
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
929
Non-LTR Retrotransposons
13.1K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
13.1K


