由父母的微生物组对后代行为的胎儿编程,以及海马内DNA甲基化和基因表达
Kevin L Gustafson1, Susheel Bhanu Busi2, Zachary L McAdams1
1Department of Pathobiology and Integrative Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO, 65201, USA.
Microbiome
|December 13, 2025
概括
母亲肠道微生物组显著影响后代的神经发育,影响海马中的行为和基因表达. 这种母性效应即使后代由不同的母亲抚养,也会持续下去.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 遗传学 遗传学 是一个
背景情况:
- 肠道微生物组会影响由中枢神经系统 (CNS) 调节的宿主行为.
- 母亲的微生物组暴露可能会影响后代的神经发育和行为.
- 有限的实验数据直接将母体微生物组与长期神经发育结果联系起来.
研究的目的:
- 研究母亲微生物组对后代神经发育和行为的影响.
- 确定母体微生物组影响后代表型的机制.
主要方法:
- 在小鼠的交叉培养实验中.
- 对海马体DNA进行全基因组DNA甲基化分析.
- 海马单细胞转录分析.
主要成果:
- 母亲微生物组主要影响后代与焦虑相关的行为,活动和体重.
- 后代的表型与母亲的微生物组特征有关,例如胆盐酸酶活性和胆酸丰富度.
- 在后代海马体中观察到与微生物组相关的DNA甲基化和基因表达的差异,母亲和后代之间保留了形状.
结论:
- 母亲的肠道微生物组对后代的神经发育和行为产生主要影响.
- 母亲微生物组选择性地影响后代海马中的DNA甲基化和基因表达.
- 这些发现为母亲微生物组在塑造后代神经发育轨迹中的作用提供了证据.
更多相关视频
07:13Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
Published on: March 25, 2016
19.4K
09:09Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
2.2K
相关概念视频
Genomic Imprinting and Inheritance
36.7K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.7K
Epigenetic Regulation
3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.7K
Epigenetic Regulation
33.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.4K
