对2-乙烯4-基酸 (2-EHHB) 的潜在内分泌生物活性进行了审查
Ronnie J Bever1, Dawn M Fallacara2, Karen Hamernik1
1U.S. Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention, Washington, DC, USA.
Journal of applied toxicology : JAT
|December 13, 2025
概括
一种类型为的2-乙基4-基酸盐 (2-EHHB) 在体内显示有雌激素活性. 这种内分泌干扰剂在低度下影响了鱼类和两动物的繁殖和发育,突出了潜在的环境风险.
科学领域:
- 环境毒理学环境毒理学
- 内分泌学 在内分泌学.
- 化学安全 化学安全
背景情况:
- ,包括2-乙4-基酸 (2-EHHB),在消费品中广泛使用.
- 人们对 parabens 的潜在内分泌干扰作用存在担忧.
- 在体外查中确定了2-EHHB作为受体 (AR) 和雌激素受体 (ER) 途径的潜在调节器.
研究的目的:
- 评估2-EHHB在体内影响内分泌通路的潜力.
- 评估内分泌干扰使用美国环保署内分泌干扰物查计划 (EDSP) 的指导方针.
- 确定对2-EHHB内分泌活性敏感的物种和作用机制.
主要方法:
- 美国环保署对六项体内研究和已发表的子宫变试验的数据进行了审查.
- 进行的EDSP Tier 1和Tier 2测定包括赫什伯格,雄性青春期,两变形测定 (AMA),鱼类短期繁殖测定 (FSTRA),幼虫两生长和发育测定 (LAGDA) 和medaka扩展的一代繁殖测试 (MEOGRT).
- 作为测试物种,利用了日本麦达卡,胖头小鱼,斑马鱼和非洲爪.
主要成果:
- 雌激素激动性是2-EHHB的最受支持的作用机制.
- 没有发现甲状腺激素干扰的明显证据.
- 在度≥5.32μg/L和FSTRA≥10.6μg/L时,Medaka (所有代) 的生育能力下降.
- 两动物的发育延迟 (LAGDA) ≥5.33μg/L,其机制尚不清楚.
- 日本的梅达卡和非洲的爪被确定为最敏感的物种.
结论:
- 2-EHHB在体内表现出雌激素活性,影响敏感水生物种的繁殖终点.
- 该研究确定了低剂量对生育能力和发育的特定影响,表明了潜在的环境风险.
- 对两动物发育迟缓背后的机制进行进一步的研究可能是有必要的.
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