挑战年龄障碍:八十岁和非八十岁的结直肠癌患者的比较结果
Engin Eren Kavak1, İsmail Dilli2, Efe Cem Erdat3
1Department of Medical Oncology, Etlik City Hospital, Ankara, Turkey. engineren2000@yahoo.com.
BMC geriatrics
|December 13, 2025
概括
患有非转移性结肠直肠癌 (CRC) 的八代人能很好地忍受标准治疗,实现与年轻患者相比的生存结果. 年龄本身不应该阻止老年人治疗意图的CRC管理.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
背景情况:
- 老年结肠直肠癌 (CRC) 患者,特别是八十岁以上的患者,由于并发症和可能的不耐受性,面临治疗挑战.
- 有限的现实世界数据存在于八十岁人的CRC治疗结果.
研究的目的:
- 为了比较八十岁的CRC患者的临床特征,治疗,毒性和生存时间,与年轻的队列进行比较.
- 评估老年CRC患者治愈意向治疗的可行性.
主要方法:
- 对111名I-III期CRC患者的回顾性队列研究 (2021年3月至2023年12月).
- 患者分为八十岁以上 (≥80岁),非八十岁以上的老年人 (65-79岁) 和非老年人 (<65岁).
- 分析包括人口统计,并发症,ECOG状态,瘤特征,治疗方法,毒性和存活率 (卡普兰-梅尔,日志等级测试).
主要成果:
- 八代人群 (35.1%) 的并发症负担较高,但ECOG分数相似.
- 组合的局部和全身治疗在78.2%的八十岁人群中被很好地容忍,在各年龄组中具有可比的毒性.
- 八代人群的无病存活率 (DFS) 和整体存活率 (OS) 是有利的,36个月的OS为91.8%.
结论:
- 患有非转移性CRC的八代人可以通过治愈意向治疗实现良好的结果.
- 年龄不应成为老年CRC患者标准瘤管理的障碍.
- 由于单中心设计和适度的样本大小,需要进一步的多中心验证.
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