轮班工作与甲状腺激素水平和-37型白蛋白之间的关联
Inaam Noori Ali1, Noor Nihad Baqer1, Hayder G Jawad1
11Scientific Research Commission, Baghdad, Iraq.
Endocrine regulations
|December 13, 2025
概括
轮班工作会破坏甲状腺功能,增加甲状腺刺激激素 (TSH) 和中白素-37 (IL-37) 水平. 这些变化与轮班工人患心血管疾病和糖尿病等慢性疾病有关.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 职业健康 职业健康 职业健康
背景情况:
- 轮班工作在各种职业中普遍存在,并且与增加的压力有关.
- 甲状腺功能障碍的症状包括体重变化,睡眠障碍和温度不耐受.
- 诸如心血管疾病和糖尿病等慢性疾病是严重的公共卫生问题.
研究的目的:
- 调查办公室和不规则轮班工作与甲状腺功能指标之间的关联.
- 检查轮班工作,血清中白蛋白-37 (IL-37) 水平和慢性疾病发展之间的关系.
- 确定轮班工作对员工健康的影响的潜在生物标志物.
主要方法:
- 该研究包括三个组:办公室工作人员,非正规工作人员和对照组 (n=85,年龄在30-55岁之间).
- 测量了三甲状腺素 (T3),甲状腺素 (T4),甲状腺刺激激素 (TSH) 和甲状腺过氧化酶 (TPO) 的血清水平.
- 使用ELISA量化了血清IL-37水平,并评估了慢性疾病的流行率.
主要成果:
- 与对照组相比,轮班工作者 (办公室和非正规) 的T3和T4水平下降.
- 在两个轮班工作组中都观察到显著升高的TSH,TPO和IL-37水平.
- 轮班工作与心脏病,高血压和糖尿病的患病率更高有关.
结论:
- 轮班工作者的IL-37和TSH水平升高可能表明免疫和激素的不良变化.
- 轮班工作对甲状腺功能构成风险,并有助于慢性疾病的发展.
- IL-37和TSH可以作为监测轮班工作对健康的影响的潜在生物标志物.
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