区分真菌角膜炎和HSV内皮角膜炎:一个比较的临床和诊断分析
Poornima Tandra1, Bhupesh Bagga1
1Shantilal Shanghvi Cornea Institute, LV Prasad Eye Institute, Hyderabad, India.
Seminars in ophthalmology
|December 13, 2025
概括
这项研究区分了真菌角膜炎 (FSKE) 和HSV内皮角膜炎 (HEK). 菌感染的关键指标包括酸边缘,卫星病变和酸细胞,有助于准确诊断.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 真菌角膜炎 (FSKE) 和简单疹病毒 (HSV) 内皮角膜炎 (HEK) 可以呈现出类似的后侧侧膜和内皮参与.
- 准确的区分对于适当的治疗和预防视力丧失至关重要.
研究的目的:
- 要区分临床特征区分真菌角膜炎与深层层和内皮干涉 (FSKE) 和HSV内皮角膜炎 (HEK).
主要方法:
- 对FSKE和HEK病例的医疗记录的回顾性审查 (2019年1月 - 2024年3月).
- 纳入标准:主要的后侧肌层透物和内皮排泄物通过微生物学或 FSKE 的共聚焦成像证实,以及 HEK 的临床/PCR 诊断.
- 临床表现和诊断发现的比较分析.
主要成果:
- 与HEK (n=32) (3.1%) 相比,FSKE病例 (n=45) 显示出显著更多的缺陷边缘,卫星病变和缺陷 (66.6%).
- 在FSKE (46.6%) 和HEK (8.8%) 中,后侧侧膜干涉率更高.
- 毛的内皮排泄物是FSKE的特征,而点状排泄物和完整的表皮在HEK中更为常见.
结论:
- 缺口边缘的存在,卫星病变,hypopyon,毛的内皮排泄物,以及后侧侧膜干涉表明真菌角膜炎.
- 完整的上皮,角膜和点状内皮排泄物有利于HSV内皮角膜炎.
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