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Updated: Jan 8, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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与APOE异形相关的tau寡合体多态体在突触毒性和播种活性上有所不同

Naomi Moreno1,2, Nikita Shchankin1,2, Leiana Fung1,2

  • 1Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, Texas, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 13, 2025
PubMed
概括

在阿尔茨海默氏病 (AD) 中,阿波蛋白E (APOE) 异型对tau的总体结构和毒性产生影响. APOE ε4相关的寡合体特别有毒,影响突触可塑性和播种活动,这表明了AD的新治疗点.

关键词:
聚合方式 聚合方式 聚合方式一些小分子.它们是多态的.突触运作的突触功能.合成毒性 合成毒性知道的 知道的 知道的

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