一种天然复合材料提取物通过调节炎症,水合和逆氧化通路来恢复皮肤屏障功能
Caijun Jin1,2, Youn Jeong Cha3, Hee Eun Kim4
1Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Journal of cosmetic dermatology
|December 13, 2025
概括
一种植物性提取物PLCP有效地减少了儿童和成人角质细胞的皮肤炎症,和氧化应激. 这种提取物还增强了皮肤水分,显示了治疗儿科皮肤病的前景.
科学领域:
- 皮肤病学和化品科学
- 在体外皮肤生物学.
- 基于植物的治疗方法
背景情况:
- 儿科皮肤疾病通常涉及炎症,和氧化应激.
- 目前的治疗方法可能有局限性,需要探索新的,安全的替代方案.
- 植物衍生化合物越来越多地被研究为皮肤学应用.
研究的目的:
- 评估一种新型复合植物提取物 (PLCP) 在关键皮肤健康参数上的疗效.
- 评估PLCP对皮肤水分,炎症,和氧化应激的影响.
- 调查皮质细胞对PLCP反应的潜在年龄相关差异.
主要方法:
- 使用的儿科 (NHEK) 和成人 (HaCaT) 角质细胞,用脂多糖 (LPS) 刺激.
- 评估PLCP对炎症 (TSLP,ET-1),,水合 (HAS) 和氧化应激 (ROS,SOD) 标志物的影响.
- 使用rt-PCR,ELISA,ROS测定和SOD活动测量进行综合分析.
主要成果:
- 在两种细胞类型中,PLCP显著抑制了LPS诱导的TSLP和ET-1分泌/mRNA水平.
- 根据剂量,PLCP上调调节了氨酸合成酶 (HAS) mRNA,表明增强了水分.
- 通过降低ROS和增加SOD活性,PLCP表现出强大的抗氧化作用.
结论:
- 在实验室中,PLCP表现出显著的抗炎,抗,保湿和抗氧化特性.
- 儿童角质细胞对PLCP的反应更加明显,这表明年龄特定的疗效.
- PLCP为治疗儿科皮肤疾病提供了一个有希望的,安全的,基于植物的选择.
相关概念视频
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
7.3K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
7.3K
Inflammatory Response
15.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.8K
Renewal of Skin Epidermal Stem Cells
2.9K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.9K
Clinical Applications of Epidermal Stem Cells
3.2K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.2K
Tissue Renewal without Stem Cells
2.1K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
2.1K
Phases of Wound Repair
7.8K
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
7.8K


