工程气体释放聚合体纳米反应器用于选择性生物催化激活
Zhezhe Li1, Suzhen Wang1, Yuzhe Ma1
1School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Angewandte Chemie (International ed. in English)
|December 13, 2025
概括
工程聚合体纳米反应器在谷刺激时释放SO2,增强膜的透性,并选择性地激活葡萄糖氧化酶以杀死癌细胞. 该系统提供受控的生物催化剂和改善治疗结果.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 化学生物学 化学生物学
背景情况:
- 聚合体是有前途的纳米反应器,但其膜透性较低,限制了基质交换.
- 聚合体内酶封装可以实现生物催化,但受控激活仍然是一个挑战.
研究的目的:
- 设计一种对谷氨 (GSH) 敏感的聚合体纳米反应器系统,用于选择性细胞内生物催化活性.
- 为了增强聚合体膜的透性,并激活葡萄糖氧化酶 (GOx) 生物催化,以应对细胞内刺激.
主要方法:
- 开发了对GSH敏感的聚合体,封装了葡萄糖氧化酶 (GOx).
- 用GSH刺激触发SO2释放并增强膜的透性.
- 在体外研究评估细胞吸收,选择性激活和杀死癌细胞的有效性.
主要成果:
- 刺激GSH诱导SO2释放,增加了聚合体膜的透性.
- GOx的生物催化激活和葡萄糖转化为H2O2在GSH过度表达的癌细胞中选择性地发生.
- 纳米反应器通过调节细胞内活性氧物种 (ROS) 水平,显示出增强的癌细胞杀伤能力.
结论:
- 开发的聚合体纳米反应器表现出基于细胞内GSH水平的选择性"开/关"生物催化激活.
- 这一战略为向药物输送和癌症治疗提供了一种新的方法.
- 该系统为开发基于聚合体的高级功能纳米反应器提供了一个有前途的平台.
相关概念视频
Enzyme-linked Receptors
85.6K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
85.6K
Positive Regulator Molecules
133.8K
To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
133.8K
Ribozymes
13.3K
The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
Ribozymes can...
Ribozymes can...
13.3K
Enzymes
93.5K
Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
93.5K


