夜间的黑激素分泌和2型糖尿病的风险:一项前性队列研究
Einar Sojakka Smith1,2, Anna Franzén1, Mats Pihlsgård1
1Perinatal and Cardiovascular Epidemiology, Department of Clinical Sciences in Malmö, Lund University, Jan Waldenströms Gata 35, 214 28 Malmö, Sweden.
The Journal of clinical endocrinology and metabolism
|December 13, 2025
概括
低夜间黑激素分泌与成人2型糖尿病风险增加有关. 这一发现突显了昼夜健康在代谢健康和糖尿病预防策略中的作用.
科学领域:
- 内分泌学和新陈代谢学
- 时间生物学 时间生物学
- 流行病学 流行病学
背景情况:
- 调节昼夜节律的荷尔蒙 - - 黑色素 (melatonin) 也会影响葡萄糖代谢.
- 不调节的黑激素分泌与2型糖尿病 (T2D) 病原发生有关.
- 将黑激素与T2D风险联系在一起的前性证据有限.
研究的目的:
- 研究夜间黑激素分泌量下降与成年人患T2D风险之间的关联.
- 提供基于人口的前性数据,了解黑激素在T2D发病率中的作用.
主要方法:
- 一项前性队列研究,涉及4491名没有T2D或黑素补充剂的成年人.
- 在第一天早晨的尿样中,通过尿液中的6 - 硫胺与肌素比率 (aMT6s/Cr) 评估的黑色素分泌.
- 随访时间平均为6.5年,T2D发病率通过国家卫生登记处确定.
主要成果:
- 黑激素分泌量最低的参与者 (MT6s/Cr的最低五分位数) 患T2D的风险明显更高.
- 即使调整了睡眠时间和睡眠中断后,这种关联仍然很强.
- 标准化log aMT6s/Cr下降1个单位与T2D风险降低有关 (HR 0.84).
结论:
- 降低夜间黑激素分泌是T2D发病率的独立危险因素.
- 这些发现强调了昼夜节律调节在维持新陈代谢健康方面的重要性.
- 进一步研究黑激素在预防糖尿病中的作用是有必要的,承认单样黑激素评估的局限性.
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