在老年人中,基于性别的差异和右心室功能和右心室肺动脉适应的决定因素
Vikneshwaren S/O Senthamil Selvan1, Jie Jun Wong1, Xiaodan Zhao1
1Department of Cardiology, National Heart Centre Singapore, Singapore, Singapore.
American journal of physiology. Heart and circulatory physiology
|December 13, 2025
概括
在健康的老年人中,女性表现出比男性更好的右心功能和适应肺动脉. 这项研究突出了基于性别的差异在老龄化的右心适应.
科学领域:
- 心脏病学 心脏病学
- 心血管生理学心血管生理学
- 老年学是指老年学的学科.
背景情况:
- 右心室 (RV) 适应心脏衰老中的肺动脉 (PA) 变化比左心室 (LV) 改造了解得更少.
- 了解RV-PA合对于评估老年人群中右心脏健康至关重要.
研究的目的:
- 评估心脏磁共振 (CMR) 衍生的RV功能指数和RV-PA合在没有心血管疾病的社区居住的老年人中.
- 为了研究VR适应衰老的性别差异.
主要方法:
- 心脏磁共振 (CMR) 用于评估RV体积 (EDV,ESV),功能 (RVEF,RV全球纵向菌株[RVGLS]) 和RV-PA合 (LV中风体积/RVESV) 在255名健康的老年人中.
- 一个RV-PA比率>1.5被定义为有效的适应.
- 进行了统计分析,以确定RV指数,RV-PA合,性别,年龄和BMI之间的关联.
主要成果:
- 女性表现出更有利的RV指数,包括更高的RVEF,更负的RVGLS和更高的RV-PA比率 (男性为2.1对1.8).
- 女性独立预测了更好的RVGLS和更小的RVESV.
- 较高的BMI和年龄较大与较大的RVESV有关,而RV-PA <1.5与较低的RVEF和较少负的RVGLS相关.
结论:
- 在健康的老年人中,CMR测量揭示了RV功能和RV-PA合的性别特异性差异,女性表现出更有利的右心表型.
- 这些发现表明需要性别特定的参考值来区分生理衰老与右心脏早期病理变化.
- 该研究提供了RV功能和RV-PA合在健康衰老队列中的生理参考数据.
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