安卓素缺乏疗法和饮食习惯影响高风险局部前列腺癌患者的肠道微生物环境
Masanori Ishida1,2, Shintaro Narita1, Hiromi Sato1
1Department of Urology, Akita University Graduate School of Medicine, Akita, Japan.
The Prostate
|December 13, 2025
概括
前列腺癌的雄激素缺乏治疗 (ADT) 增加了肠道Ruminococcus 2,与降低丸激素和降低n-3脂肪酸有关. 需要进一步的研究来理解这些肠道微生物组在ADT期间的变化.
科学领域:
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
- 内分泌学 在内分泌学.
背景情况:
- 接受雄激素缺乏治疗 (ADT) 的前列腺癌患者会经历各种副作用.
- 人们越来越认识到肠道微生物在治疗反应和副作用中的作用.
- 了解肠道微生物群,水平和饮食之间的相互作用对于管理ADT至关重要.
研究的目的:
- 研究接受ADT的高风险前列腺癌患者的肠道微生物特征,副作用,总水平 (TS) 和饮食习惯之间的关系.
- 在ADT前后分析肠道微生物群组成的变化.
- 探索特定肠道细菌,TS水平和营养摄入量之间的相关性.
主要方法:
- 对接受ADT的高风险局部性前列腺癌患者的前性研究 (2021年3月 - 2022年8月).
- 分析肠道微生物特征,实验室检测,饮食摄入量,以及ADT前后 (3个月) 的TS水平.
- 统计分析以确定显著差异和相关性.
主要成果:
- 在ADT前和之后没有观察到肠道微生物群的整体多样性 (α和β) 发生显著变化.
- 在ADT之后,Ruminococcus 2和[Eubacterium]反动物群的相对丰度显著增加.
- 较高的Ruminococcus 2丰度与较低的ADT后TS水平 (<20 ng/dL) 有关.
- 处理前摄入的n-6多不和脂肪酸与Romboutsia和Fusicatenibacter正相关.
- 摄入的n-3多不和脂肪酸与Ruminococcus 2和Veillonella有负相关性.
结论:
- 短期的ADT增加了前列腺癌患者的肠道Ruminococcus2,与降低TS水平相关.
- 鲁米诺菌2的丰富性与n-3多不和脂肪酸摄入量有负相关性.
- 进一步的研究对于验证这些发现和阐明肠道微生物组在前列腺癌ADT期间的作用至关重要.
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