利用nd:YAG激光技术,对抗酵母驱动的乳腺菌病的抗真菌耐药性
Taraneh Razaviyoun1, Parvin Mansouri2, Seyed Jamal Hashemi3
1Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Taraneh.Razaviyoun@gmail.com.
Lasers in medical science
|December 13, 2025
概括
长脉冲的Nd:YAG激光 (NDYL) 与抗真菌药物相结合,在体外显著提高了对酵母乳菌的疗效. 凯托可纳和伊特拉可纳显示出最明显的协同效应,增强抗真菌活性.
科学领域:
- 医学真菌学 医学真菌学
- 皮肤病学 皮肤病学
- 激光医学是激光医学.
背景情况:
- 甲状腺炎是一种常见的指甲感染,具有具有挑战性的治疗结果.
- 传统的抗真菌疗法面临的局限性包括耐药性和患者不良遵从性.
- 作为抗真菌药物补充剂的长脉冲Nd:YAG 1064nm激光 (NDYL) 对于酵母菌相关的甲状腺瘤的疗效仍在研究中.
研究的目的:
- 评估NDYL与四种抗真菌剂 (基托可纳,伊特拉可纳,沃里可纳,特尔比纳) 结合的体外协同效应,与桃菌病患者的临床酵母分离物相比.
- 评估NDYL对抗真菌敏感性的影响,无论是重要的指甲和培养酵母菌群.
主要方法:
- 通过ITS PCR测序识别出了来自乳菌菌的临床酵母分离物.
- 使用CLSI磁盘扩散方法 (M44-A2) 进行了抗真菌敏感性测试.
- 爪和培养酵母菌群被暴露在标准化的NDYL参数中,并通过抑制区直径测量抗真菌活性.
主要成果:
- NDYL显著增强了凯托可纳 (KET) 和伊特拉可纳 (ITC) 的抗真菌活性,KET在指甲削物中实现了100%的灵敏度改善.
- 沃里康纳 (VRC) 和特尔比纳 (TRB) 也显示出适度,持续增强的抗真菌功效.
- 辐射温度保持在42°C以下,表明主要非热作用机制.
结论:
- 作为一种辅助疗法,NDYL显示出有前途的结果,以改善酵母相关乳菌的抗真菌治疗结果.
- 在体外观察到的协同效应需要进一步的体内研究,以确定临床适用性和优化治疗方案.
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