加快生物衰老,生活方式因素和认知功能的遗传易感性之间的相互作用:一个社区研究
Tianpei Ma1, Xin Chen1, Qingwen Zhao1
1Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China, Sichuan.
概括
加快的生物衰老与老年人的认知能力下降有关. 不健康的生活方式加剧了这种影响,强调了生活方式的改变对大脑健康的影响.
科学领域:
- 老年学和认知神经科学
- 生物标志物和衰老研究
- 公共卫生和生活方式干预措施
背景情况:
- 认知障碍在老年人群中构成了重大挑战.
- 在认知健康中,生物衰老,生活方式和遗传学之间的复杂相互作用尚未完全理解.
- 了解这些因素对于开发有效的认知衰退干预措施至关重要.
研究的目的:
- 调查加速生物衰老与中国老年人认知障碍之间的关联.
- 检查生活方式因素是否会改变生物衰老与认知功能之间的关系.
- 探索遗传背景对这些关联的影响.
主要方法:
- 一项涉及7033名中国老年人 (2022-2023) 的横截面研究.
- 使用10个生物标志物来确定生物年龄;加速衰老是生物与时间年龄的残余.
- 用中国迷你精神状态检查 (C-MMSE) 评估认知功能;评估生活方式和遗传风险 (多基因分数,APOE ε4).
主要成果:
- 加快的生物衰老与较低的C-MMSE得分以及增加认知障碍的几率相关.
- 不健康的生活方式显著加剧了生物老年人的认知障碍.
- 无论遗传背景如何,加速衰老和不健康的生活方式的人表现出最差的认知功能和最高的损伤风险.
结论:
- 加快的生物衰老是老年人认知障碍的重要危险因素.
- 改变生活方式,特别是养成更健康的习惯,是缓解与年龄相关的认知衰退的一个有希望的途径.
- 这些发现强调了生活方式干预在促进跨不同遗传背景的认知健康的重要性.
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