高级泌尿癌共识会议 (AUC3) 2025:关于对细胞和尿路癌症的管理的专家共识
Rana R McKay1, Sumanta Pal2, Wanling Xie3
1Department of Medicine, Urology, and Radiation Medicine and Applied Sciences, University of California-San Diego, La Jolla, California, USA.
CA: a cancer journal for clinicians
|December 13, 2025
概括
专家共识指导高级细胞癌 (RCC) 和尿路癌 (UTC) 治疗,建议辅助 pembrolizumab 治疗高风险的 RCC 和局部 UTC 的新辅助治疗. 建立了关键的治疗序列,尽管研究缺口仍然存在.
科学领域:
- 尿瘤学 尿瘤学
- 临床瘤学临床瘤学
- 基于证据的医学是基于证据的医学.
背景情况:
- 细胞癌 (RCC) 和尿路癌 (UTC) 的治疗环境变得越来越复杂.
- 对临床医生来说,最佳的疗法序列和选择是具有挑战性的.
- 2025年高级泌尿癌共识会议的目的是解决这些复杂问题.
研究的目的:
- 建立基于证据的专家共识建议,用于管理先进的RCC和UTC.
- 在复杂的临床场景中提供治疗选择和顺序的指导.
- 确定泌尿瘤学的关键研究优先事项.
主要方法:
- 一个经过修改的Delphi过程,涉及51名多学科专家.
- 在与RCC和UTC管理相关的问题上反复建立共识.
- 会议前后进行投票,分析重点是会议后的反应 (达成共识时≥75%的同意,达成强有力的共识时>90%).
主要成果:
- 关于辅助布罗利祖马布治疗高风险RCC和局部UTC的新辅助治疗的强有力的共识.
- 关于恩福图马布 (vedotin) + pembrolizumab作为转移性UTC的前线治疗的强有力的共识.
- 在RCC的前线疗法进展后,关于血管内皮生长因子受体-铁氨酸激酶抑制剂治疗的共识,但在其他关键领域缺乏共识.
结论:
- 会议为复杂的RCC和UTC管理提供了基于证据的指导.
- 在一些领域显著的研究差距和缺乏共识强调了需要改进患者选择和前性研究.
- 代的共识过程旨在解决不断变化的治疗模式,并优化患者的治疗结果.
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