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法医科学中的数字病理学:对文献的系统审查

Laura Ambrosi¹, Federica Amirante², Simona Nicolì³

¹Interdisciplinary Department of Medicine, Section of Legal Medicine, University of Bari Aldo Moro, Piazza Giulio Cesare 11, Bari, Italy.

Forensic science, medicine, and pathology

|December 13, 2025

概括

数字病理学 (DP) 和全幻灯片成像 (WSI) 对法医有前景,但需要严格的验证才能合法使用. 实施标准化,可审计的工作流程可以确保在医疗法律环境中可复制,可在法庭上辩护的证据.

科学领域:

法医病理学法医病理学
数字病理学数字病理学
医疗成像医学成像

背景情况:

数字病理学 (DP) 和全幻灯片成像学 (WSI) 在临床环境中建立.
由于严格的证据标准,它们在法医中的应用不太明确.
法医使用需要强大的验证,可审计性和保管链.

研究的目的:

系统地审查DP和WSI在法医,尸检和死后环境中的应用.
评估DP对医疗法律工作流程的准备程度.
确定成功的法医采用要求.

主要方法:

在PubMed,Scopus和Web of Science的系统文献综述.
纳入标准:在法医,尸检或死后环境中进行同行评审的人类研究.
数据提取侧重于研究设计,组织,设备,软件和结果 (诊断协议,定量指标,验证,QA).

主要成果:

21项研究符合361个记录中的纳入标准.
15项研究集中在使用死后材料 (例如神经病理学,形态测量) 的诊断知识上.
5项研究有直接的法医目的,包括案例验证和核心法医测试.

结论:

DP在技术上为医疗法律工作流程做好了准备.
与临床环境相比,目前的法医采用率很低.
法医采用需要CAP风格的验证,可追溯的管道,污点治理和强度测试,以获得可重复的,可以在法庭上辩护的证据.

关键词:

数字组织病理学数字组织病理学数字病理学数字病理学法医医学法医学的研究.整个幻灯片图像的图像.

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