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不确定的慢性乙型肝炎的临床特征肝脏活检和没有肝脏活检的患者

Ye Xiong¹, Jian Wang^1,2,3, Yuchen Song⁴

¹Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China.

Hepatology research : the official journal of the Japan Society of Hepatology

|December 13, 2025

概括

在不确定的阶段,只有9.8%的慢性乙型肝炎 (CHB) 患者接受了肝活检. 这些活检显示出更高的HBVDNA和非侵入性纤维化得分,这表明它们可能不代表整个不确定的CHB人口.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
临床医学临床医学

背景情况:

慢性乙型肝炎 (CHB) 是一个重要的全球健康问题.
在不确定的阶段,相当数量的CHB患者经历了严重的肝损伤.
肝脏活检,一个明确的诊断工具,在这个患者群体中使用不足.

研究的目的:

为了比较未确定阶段的CHB患者的临床特征,这些患者接受了肝脏活检,与那些没有接受肝脏活检的人相比.
确定与决定在不确定的CHB患者中进行肝活检相关的因素.

主要方法:

根据AASLD 2018指南,对2928名未经治疗的CHB患者进行了回顾性分析,这些患者被归类为未确定阶段.
人口,病毒和肝纤维化标志物与肝活检和没有肝活检的患者之间的比较.

主要成果:

在不确定的CHB患者中,只有9.8% (288/2928) 接受了肝活检.
接受活检的患者年龄较大,HBV DNA 水平较高,非侵入性纤维化得分 (APRI,FIB-4) 和肝硬度较高.
较低的血小板计数和较高的HBVDNA水平与接受肝活检有显著的关联.

结论:

在不确定的CHB患者中,肝脏活检率低,凸显出诊断和管理方面的潜在差距.
接受活检的患者代表了一个潜在的更先进的肝病标志物的子组.
在这个选定的群体中,肝活检的结果应谨慎解释,可能无法对所有不确定的CHB患者进行概括.

关键词:

慢性乙型肝炎慢性乙型肝炎一个不确定的阶段.肝脏活检活检肝脏活检

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