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Updated: May 2, 2026

An Optogenetic Approach for Assessing Formation of Neuronal Connections in a Co-culture System
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An Optogenetic Approach for Assessing Formation of Neuronal Connections in a Co-culture System

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针对CLN3疾病患者特异性iPSC衍生的神经元原生细胞模型中小分子查的协议

Ramu Venkatesan1, Paul C Trippier2

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68106, USA.

STAR protocols
|December 13, 2025
PubMed
概括

这项研究详细介绍了一项用于选最常见的儿童神经退行性疾病 - - CLN3疾病的潜在治疗方案的方案,该方案使用来自患者的干细胞和神经元前代细胞.

关键词:
细胞分化的细胞分化.高通量选的高通量选干细胞是一种干细胞.

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EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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