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在社区居住的老年人中,骨质疏松症和认知功能之间的关联:来自美国队列的证据
Konstantinos Prokopidis1, Stefano Cacciatore2, Nicola Veronese3,4
1Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
概括
骨髓缩症,低骨密度和肌肉强度的结合,与老年人认知功能较差有关. 这凸显了需要采用综合方法来维持老龄化人口的骨和大脑健康.
科学领域:
- 老年学是一门学科.
- 骨和肌肉健康 骨和肌肉健康
- 认知神经科学 认知神经科学
背景情况:
- 骨质疏松症,定义为骨质疏松症/骨质疏松症和手握强度低 (HGS) 的共存,在老年人群中越来越令人担忧.
- 在65岁及以上的成年人中,研究了骨质疏松症和认知功能之间的特定领域的关联.
研究的目的:
- 为了检查骨质疏松症和老年人的认知表现之间的关系.
- 确定受骨矿物质密度降低和肌肉强度低的综合条件影响的特定认知领域.
主要方法:
- 利用了2011-2014年周期国家健康和营养检查调查 (NHANES) 的数据.
- 用骨密度和肌肉强度的HGS的腿部T-score来定义骨质疏松症.
- 通过数字符号替换,延迟回忆,入侵词数和动物流利性测试来评估认知功能.
- 采用线性回归模型来分析双向关联.
主要成果:
- 这项研究包括1355名老年人 (平均年龄70.3岁,57%是女性).
- 低HGS的骨质疏松与数字符号测试 (处理速度) 的表现差显著相关.
- 低HGS的骨质疏松症与数字符号测试中的表现较差有显著的关联.
- 对于孤立的骨质疏松症或骨质疏松症没有低HGS,没有发现显著的关联.
结论:
- 骨质疏松症与认知能力受损有关,特别是在处理速度和记忆方面.
- 研究结果表明,综合查对于肌肉骨健康和认知功能的重要性.
- 建议针对老年人群进行针对骨/肌肉和认知健康的多维干预.
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