在患有慢性疼痛的患者中评估柔性布普伦诺芬剂量
Sarah Setoudeh1,2, Rebecca Hoss3, Aletha Loeb1
1University of California, Davis Health, Sacramento, California, USA.
Journal of pain & palliative care pharmacotherapy
|December 13, 2025
概括
灵活的布普伦诺芬剂量,包括计划和按需 (PRN) 选项,显示了慢性疼痛管理的前景. 灵活治疗方案的患者在布普伦诺芬治疗中停留的时间比单独服用计划剂量的患者更长.
科学领域:
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
- 临床研究 临床研究
背景情况:
- 布普伦诺芬是一种混合激动剂-对抗剂阿片类药物,与完全激动剂相比,在长期使用中提供了更安全的个人资料.
- 对于慢性疼痛患者的柔性布普伦诺芬剂量策略存在有限的文献.
- 片类药物使用障碍 (OUD) 患者被排除在外,专注于非OUD慢性疼痛管理.
研究的目的:
- 研究在慢性疼痛患者群体中使用灵活的布普伦诺芬剂量方案.
- 为了比较不同剂量策略的布普伦诺芬治疗持续时间.
主要方法:
- 回顾性,单中心,观察性研究设计.
- 纳入标准:成年人 (18+) 患有慢性疼痛处方布普伦诺芬,不包括OUD诊断.
- 布普伦诺芬治疗方案的分析:计划,计划+PRN,单独的PRN,计划+PRN全μ-阿片类药物激动剂.
主要成果:
- 在691名被审查的患者中,有401人符合纳入标准.
- 预定的布普伦诺芬是最常见的 (84.4%),其次是预定的+PRN (9.2%).
- 灵活剂量 (预定+PRN) 患者的治疗持续时间 (HR 3.50) 与预定单独相比显著更长.
结论:
- 灵活的布普伦诺芬剂量,具体计划加上PRN,用于慢性疼痛管理.
- 灵活的剂量策略与较长的布普伦诺芬治疗保留时间有关.
- 预定加PRN布普伦诺芬是治疗慢性疼痛的可行选择.
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