多发性硬化症的斋月禁食:一个系统的审查.
Ahad Nourmohammad1, Meysam Zorriyeh-Sheikhali2, Sarvin Sanaie3
1Research Center for Evidence-Based Medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
Multiple sclerosis and related disorders
|December 13, 2025
概括
斋月禁食可以改善轻度残疾的多发性硬化症 (MS) 患者的生活质量. 然而,较高的残疾和较长的疾病持续时间增加了在斋月期间MS激活的风险.
科学领域:
- 神经学 神经学
- 临床医学 临床医学
- 公共卫生 公共卫生
背景情况:
- 斋月的遵守包括从日出到日落的每日禁食.
- 斋月禁食对多发性硬化症 (MS) 患者的影响是一个重大的临床问题.
- 了解这些影响对于斋月期间的患者管理至关重要.
研究的目的:
- 系统地审查有关斋月禁食对患有多发性硬化症 (MS) 患者的影响的现有临床证据.
- 评估斋月纪念对多发性硬化症患者的安全性和潜在益处.
主要方法:
- 在主要的科学数据库 (PubMed,Scopus,Embase,Web of Science) 中进行了全面的文献搜索.
- 采用了遵循JBI和PRISMA指南的系统审查方法.
- 使用JBI工具对偏见风险进行了批判性评估,不包括非同行评审的文章.
主要成果:
- 四项研究 (n=481) 符合资格标准,重点是地中海东部地区的MS患者.
- 斋月禁食与增加多发性硬化症复发率或残疾恶化无关.
- 人们在生活质量和认知功能方面有所改善,尽管较高的残疾和疾病持续时间存在风险.
结论:
- 有限的证据表明,斋月禁食可能会提高轻度残疾的多发性硬化症患者的生活质量.
- 没有发现显著的不良影响,但由于研究规模较小,研究结果需要谨慎解释.
- 更高的残疾水平和更长的疾病持续时间是斋月期间MS恶化的危险因素.
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