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与自闭症谱系障碍相关的环境研究的系统证据地图的协议:aWARE项目

Anisha Singh¹, Johanna R Rochester², Robyn Blain²

¹National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States.

Environment international

|December 13, 2025

概括

环境暴露可能导致自闭症谱系障碍 (ASD). 本研究概述了一种系统证据图 (SEM) 方法,用于组织对早期暴露和ASD的研究,创建一个名为aWARE的交互式工具.

科学领域:

环境健康环境健康
神经发育障碍神经发育障碍
毒理学毒理学毒理学

背景情况:

越来越多的证据将环境化学物质暴露与自闭症谱系障碍 (ASD) 联系起来.
这项研究的复杂性阻碍了对潜在关联的综合和理解.
需要一个系统的方法来绘制现有证据.

研究的目的:

描述一个系统的证据地图 (SEM) 方法.
确定和描述早期环境暴露和ASD的研究.
为自闭症研究开发一个互动的基于网络的工具 (aWARE).

主要方法:

在PubMed,科学网和Scopus中进行全面的文献搜索.
根据使用DistillerSR®的早期环境暴露标准来选择产品.
使用DEXTR软件进行数据提取和分类,在Tableau中可视化为SEM.
纳入自闭症社区的投入.

主要成果:

该协议详细说明了aWARE工具的预先规定的SEM方法.
该aWARE工具将提供一个可查询和交互的数据库.
SEM将分类暴露,证据流,研究设计和ASD结果.

结论:

该协议确保ASD环境暴露研究的透明度和可复制性.
开发的aWARE工具将通过合成复杂的证据来推动ASD研究.
社区的贡献将提高研究资源的实用性和相关性.

关键词:

自闭症自闭症自闭症自闭症谱系障碍 (ASD) 是一种环境暴露环境暴露环境暴露系统的证据地图 (SEM)

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