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患有低氧性缺血性脑病的婴儿的葡萄糖与乳酸盐比率,并接受低温治疗

Carlo Dani¹, Giulia Remaschi², Elia Benelli²

¹Department of Neurosciences, Psychology, Drug Research, and Child Health, University of Florence, Florence, Italy; Division of Neonatology, Careggi University Hospital of Florence, Florence, Italy.

Early human development

|December 13, 2025

概括

在24小时治疗性低温 (TH) 后的血糖和乳酸水平,以及MRI得分,预测了患有缺氧性缺血性脑病变 (HIE) 的婴儿的神经发育结果. 葡萄糖与乳酸盐的比率没有显示出预测价值.

科学领域:

新生儿神经学新生儿神经学
婴儿脑损伤中的生物标志物
神经发育结果的神经发育结果

背景情况:

接受治疗性低温 (TH) 治疗的缺氧缺血性脑病变 (HIE) 的婴儿具有可变的神经发育结果.
以前的研究表明,葡萄糖与乳酸盐的比率和血糖/乳酸盐水平预测了结果.

研究的目的:

确认或驳斥葡萄糖与乳酸比率,血糖和乳酸值以及神经成像与TH治疗的HIE婴儿的神经发育结果之间的相关性.

主要方法:

对48名接受TH治疗的HIE婴儿进行了回顾性研究.
在TH之前和期间记录了葡萄糖与乳酸盐的比例,葡萄糖和乳酸盐水平.
评估结果使用EEG,脑MRI和贝利-III尺度在经过调整的年龄.

主要成果:

后勤回归显示,TH后24小时的葡萄糖和乳酸盐水平与不利结果正相关 (P=0.027和P=0.041).
核磁共振成绩也与不良结果正相关 (P=0.037).
葡萄糖与乳酸盐的比率没有预测神经发育的结果.

结论:

葡萄糖与乳酸的比率不是接受TH的HIE婴儿的神经发育结果的可靠预测指标.
24小时TH和脑MRI发现的血糖和乳酸水平与不良结果的风险增加有关.
需要进一步的研究来探索其他潜在的生物标志物来预测HIE的结果.

关键词:

葡萄糖是一种葡萄糖.葡萄糖与乳酸盐的比率是什么低毒性缺血性脑内科病变 (hypoxic ischemic encephalopathy) 是一种高毒性缺血性脑内科病变.乳酸盐是一种乳酸盐.磁共振成像技术磁共振成像技术

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