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多发性硬化症患者的血液神经丝光链:系统性审查和更新的元分析

Rasoul Ebrahimi¹, Mojtaba Seifi², Mohammad Mahdi Masouri²

¹Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Experimental gerontology

|December 13, 2025

概括

与对照组相比,在多发性硬化症 (MS) 患者和所有主要的MS亚型中,血液神经丝光链 (NfL) 升高. 这表明NfL是MS进展和亚型分化的潜在生物标志物.

科学领域:

神经学神经学
生物标志物研究生物标志物研究
神经免疫学神经免疫学

背景情况:

多发性硬化症 (MS) 是一种慢性神经系统疾病,其特征是炎症和神经退行.
神经纤维光链 (NfL) 是在轴突损伤时释放到血液中的蛋白质.
评估血液NfL水平可以提供有关MS疾病活动和进展的见解.

研究的目的:

在多发性硬化症 (MS) 患者中系统评估血液神经丝光链 (NfL) 水平.
为了比较MS患者和健康对照人群之间的NfL水平.
分析NfL水平在MS的不同亚型,包括复发性缓解性MS (RRMS),二次渐进性MS (SPMS),和初级渐进性MS (PPMS).

主要方法:

在PubMed和Web of Science上进行了系统的文献搜索,截至2025年2月20日.
包括的研究报告了MS患者和对照组的血液NfL水平.
用基于异质性的随机或固定效应模型进行了元分析 (I2).

主要成果:

分析了68项涉及19,159名参与者的研究.
与对照组相比,MS患者的血液NfL水平显著更高 (SMD = 0.78).
与对照组相比,在所有多发性硬化症亚型 (RRMS,SPMS,PPMS) 中观察到高NfL水平.

结论:

血液NfL是MS中神经轴突损伤的敏感生物标志物.
NfL水平可以帮助区分多发性硬化症的亚型.
需要进一步的研究来验证NfL在治疗多发性硬化症方面的临床实用性.

关键词:

血液中的生物标志物.进行元分析分析.多发性硬化症是多发性硬化症.在 NfL 中,它是NfL.

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