相关实验视频

Updated: Jan 8, 2026

Mouse Microsurgery Infusion Technique for Targeted Substance Delivery into the CNS via the Internal Carotid Artery

Mouse Microsurgery Infusion Technique for Targeted Substance Delivery into the CNS via the Internal Carotid Artery

Published on: January 31, 2017

通过外基因介导的斯库泰拉林递送增强了BBB透和微质向在抗病毒神经保护中的作用

Chunlian Song¹, Shengjia Sun¹, Ting Li¹

¹School of Veterinary Medicine of Yunnan Agricultural University, Kunming, Yunnan 650201, China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|December 13, 2025

概括

小鼠大脑外基因组有效地通过血脑屏障传递scutellarin,增强其抗神经炎症作用. 这种新的药物输送系统在治疗神经疾病方面表现有前途.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
生物技术是生物技术.

背景情况:

来自Erigeron breviscapus的scutellarin在神经疾病中具有治疗潜力.
它的临床使用受到溶解性差,生物可用性低以及无法穿越血脑屏障 (BBB) 的阻碍.

研究的目的:

开发一种新的药物输送系统,使用小鼠大脑组织衍生的外体来增强在BBB的scutellarin输送.
为了评估外体递送的甲在治疗神经炎症中的疗效.

主要方法:

从小鼠大脑组织中用超离心法分离出外体.
斯库特拉林通过超声波加载到外体中.
实验室BBB模型和PRV感染的微细胞模型被用于评估药物输送和抗神经炎症作用.

主要成果:

外体载荷斯库特拉林与自由斯库特拉林 (13.5%) 相比,BBB透率 (41%) 显著更高.
证实了有效的细胞吸收,特别是微质细胞 (98%).
在体内研究表明,外体细胞在脑组织中积累了超过24小时.
外体递送的斯库特拉林通过降低CD86的调节和提高CD206的调节来抑制病毒复制和调节微质极化.

结论:

由大脑衍生出来的外体作为一个有效的输送系统,克服了BBB的局限性.
这种方法增强了scutellarin的抗神经炎症作用,这表明它有可能治疗神经炎症疾病.

关键词:

血液-大脑屏障是什么?药物交付是药物交付的过程.外基因组是外基因组的组成部分.微质的极化是微质的极化斯库特勒拉里纳是什么意思

更多相关视频

A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA

A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA

Published on: December 26, 2015

Delivery of Antibodies into the Brain Using Focused Scanning Ultrasound

Delivery of Antibodies into the Brain Using Focused Scanning Ultrasound

Published on: July 18, 2020

相关概念视频

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...