饮食模式与异常性肺纤维化发病率之间的关联:一个队列研究
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Updated: Jan 8, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
Yonghao Li1, Xinran Dou1, Hui Li1
1The Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, National Health Commission (NHC) Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
坚持DASH,MEDAS和MIND等健康饮食与较低的异常性肺纤维化 (IPF) 风险有关. 这种保护作用部分归因于表型衰老加速的减少,这表明饮食对肺部衰老有影响.
科学领域:
- 肺部医学 肺部医学
- 营养流行病学 营养流行病学
- 老年学是一门学科.
背景情况:
- 异形性肺纤维化 (IPF) 是一种渐进的,与年龄相关的肺病,具有有限的可修改风险因素.
- 健康饮食模式在IPF风险和进展中的作用尚不清楚.
- 现型衰老加速是衰老和疾病风险的新兴生物标志物.
研究的目的:
- 调查遵守DASH,MEDAS和MIND饮食模式和发生IPF之间的关联.
- 探索是否表型加快年龄介导了饮食和IPF风险之间的关系.
主要方法:
- 来自英国生物库的196,473名参与者的分析,随访时间中位数为12.4年.
- 通过使用重复的24小时回忆问卷来评估饮食摄入量.
- 考克斯的比例危险模型和调解分析,以评估饮食-IPF关联和通过表型年龄加速调解.
主要成果:
- 对DASH,MEDAS和MIND饮食的更高坚持与IPF风险降低有显著的关联.
- 坚持度最高与最低四分位数的危险比为DASH的0.75,MEDAS的0.53和MIND的0.66.
- 现型年龄加速部分介导了这些饮食模式与IPF的保护性关联.
结论:
- 坚持健康的饮食模式与患上IPF的风险较低有关.
- 降低表型年龄加速在调解饮食-IPF关联方面发挥了部分作用.
- 促进健康饮食可能有助于减轻与年龄相关的肺部疾病 (如IPF) 的负担.
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