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Updated: Jan 8, 2026

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红氧依赖蛋白S-氨基化控制了AML中阿扎西提丁的敏感性和耐药性

Dušan Nemes1, Michaela Myšáková1, Lubomír Minařík2

  • 1BIOCEV, First Faculty of Medicine, Charles University, Vestec, 25250, Czech Republic; Faculty of Science, Charles University, Prague, 128 00, Czech Republic.

Redox biology
|December 13, 2025
PubMed
概括

急性髓性白血病 (AML) 的耐药性涉及改变的氧化还原代谢. 恢复蛋白质S-氨基化使抗AML细胞对阿扎西提丁治疗产生敏感性.

关键词:
急性髓性白血病是什么?急性髓性白血病是什么?亚扎西提丁胺是一种阿扎西提丁.囊氨酸的氧化方式造成的DNA损伤是DNA损伤.药物耐药性 药物耐药性 药物耐药性氧酶系统的使用.低甲基化疗法是一种低甲基化疗法.电解蛋白质组学 电解蛋白质组学 电解蛋白质组学在S-Glutathionylation的过程中,S-Glutathionylation的作用是什么?

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