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Updated: Jan 8, 2026

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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在ALS中,TDP-43功能障碍影响了UPF1依赖的mRNA代谢

Francesco Alessandrini1, Matthew Wright1, Tatsuaki Kurosaki2

  • 1The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Neuron
|December 13, 2025
PubMed
概括

上框架转移蛋白1 (UPF1) 功能障碍影响了肌缩侧硬化症 (ALS) 中的运动神经元健康. 这项研究揭示了UPF1的存在.

关键词:
3′ UTR 的时间.这就是ALS.这就是APA APA APA.没有NMD,没有NMD.在TDP-43中使用.在 UPF1 的情况下.替代性的多基化.骨髓缩侧面硬化症 (ALS) 是一种从iPSC衍生的运动神经元.无意义介导的mRNA衰变是无意义介导的

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