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相关概念视频

Obesity01:24

Obesity

1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
221
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

198
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
198
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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相关实验视频

Updated: Jan 8, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
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Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

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中国的肥胖问题:当前进展和未来前景

Xiong-Fei Pan1, Zhong-Ze Fang2, Lingli Zhang3

  • 1Section of Epidemiology and Population Health and Department of Gynecology and Obstetrics, Ministry of Education Key Laboratory of Birth Defects and Related Diseases of Women and Children and Children's Medicine Key Laboratory of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China; Shuangliu Institute of Women's and Children's Health, Shuangliu Maternal and Child Health Hospital, Chengdu, Sichuan, China; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

The lancet. Diabetes & endocrinology
|December 13, 2025
PubMed
概括

在中国,肥胖率正在上升,尽管有新的治疗方法,如GLP-1受体激动剂. 主要挑战包括诊断标准,国家目标和基于证据的治疗算法,以获得有效的肥胖护理.

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科学领域:

  • 公共卫生 公共卫生
  • 临床研究 临床研究
  • 卫生政策 卫生政策

背景情况:

  • 在中国,超重和肥胖的患病率不断上升.
  • 与肥胖相关的重大健康和经济后果.
  • 越来越多地关注肥胖症作为国家公共卫生问题.

研究的目的:

  • 批判性地检查肥胖管理的最新进展.
  • 识别公共卫生,政策和临床实践中的当前和新兴挑战.
  • 提出综合,以人为中心的系统,以提供全面的肥胖护理.

主要方法:

  • 审查国家政策框架和技术指导方针.
  • 对生活方式干预和药物治疗的证据分析.
  • 在中国检查已批准的GLP-1受体激动剂用于体重管理.

主要成果:

  • 国家政策和指导方针提高了对肥胖的认识.
  • 新的GLP-1受体激动剂提供了扩展的治疗选择.
  • 在诊断标准,国家目标和药物治疗算法方面仍然存在挑战.

结论:

  • 肥胖护理的进步受到持续挑战的威胁.
  • 需要整合系统来解决社会经济,环境和行为因素.
  • 呼吁在全球卫生框架内提供全方位的肥胖护理.