相关实验视频
Updated: Jan 8, 2026

05:39
Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
Published on: May 16, 2025
520
每天都有一个新的融合? - 关于皮肤病理学的最新发现的最新情况
Eric C Honaker1, Ruifeng Ray Guo2, Carina A Dehner3
1Department of Pathology and Laboratory Medicine, Indiana University, IN, USA.
Human pathology
|December 13, 2025
概括
分子诊断正在通过识别皮肤瘤中的基因融合来彻底改变皮肤病理学. 了解这些融合驱动的癌症有助于诊断,预后和治疗决策.
科学领域:
- 皮肤病理学 皮肤病理学
- 分子诊断学 分子诊断
- 在瘤学瘤学.
背景情况:
- 分子诊断越来越多地融入了皮肤病理学.
- 这揭示了各种皮肤瘤中致癌基因融合的多样化景观.
- 这些由融合驱动的瘤具有独特的特征,影响诊断和治疗.
研究的目的:
- 审查最近融合相关皮肤瘤的进展.
- 为了突出新出现的分子子集和反复重排.
- 为病理学家提供实用参考.
主要方法:
- 关于融合相关皮肤瘤的最新文献的综述.
- 对形态相关性和免疫组织化学替代物的讨论.
- 强调下一代测序的作用.
主要成果:
- 在斯皮茨瘤,MITF通路激活瘤,介质瘤和副瘤中识别新兴分子子集.
- 形态特征与底层基因融合的相关性.
- 在复杂的情况下展示下一代测序的价值.
结论:
- 对融合驱动皮肤病理学的最新理解对于准确的分类至关重要.
- 承认这些实体有助于预测治疗脆弱性.
- 本综述作为实践病理学家的当代参考.
相关概念视频
Skin Diseases and Disorders
5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K
Confocal Fluorescence Microscopy
19.9K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
19.9K
Skin Cancer
5.7K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.7K
Changes in Skin Color: Clinical Perspectives
3.2K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.2K

