相关实验视频
Updated: Jan 8, 2026

09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
16.5K
基于纳米技术的新型药物输送系统的最新发展,用于皮肤和皮肤应用
Nazlı Erdoğar1, Betül Gür2, Dilara Örgül3
1Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
概括
基于纳米技术的药物递送系统 (NDDS) 通过克服皮肤屏障挑战来增强局部和皮肤间的治疗方法. 本综述探讨了先进的纳米系统,以改善皮肤应用中的药物输送和安全性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 角层 (SC) 构成了局部和透皮药物输送的重要障碍,限制了治疗生物可用性.
- 基于纳米技术的药物递送系统 (NDDS) 提供了有前途的解决方案,以提高药物透性,溶解性和释放动力学.
- 有效地向皮肤 (局部) 或皮肤 (全身) 目标传递需要不同的纳米载体设计策略.
研究的目的:
- 批判性地审查NDDS在局部和透皮应用方面的最新进展.
- 分析各种纳米系统及其物理化学特性,以优化药物性能.
- 评估临床方面,包括皮肤中纳米载体的体内命运,生物相容性和安全性.
主要方法:
- 对皮肤应用的基于纳米技术的药物输送系统的文献综述.
- 关键纳米系统的分析:基于脂质的纳米颗粒,聚合物纳米颗粒,囊状结构,纳米乳液,纳米纤维,树脂和小粒.
- 皮肤向与皮肤穿透的设计策略的比较.
主要成果:
- 包括基于脂质的纳米颗粒和纳米乳液在内的NDDS显示出改善药物透性和溶解性的潜力.
- 特定的设计策略使得选择性向皮肤或皮肤外通路径成为可能.
- 了解纳米载体的体内命运和安全概况对于临床转化至关重要.
结论:
- 在克服皮肤屏障限制以提高药物输送方面,NDDS代表了重大进展.
- 量身定制的纳米载体设计对于在皮肤应用中实现所需的治疗结果至关重要.
- 对纳米药物的临床安全性和疗效进行进一步的研究是成功转化为患者护理的必要条件.
相关概念视频
Drug Delivery: Miscellaneous Routes
694
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
694
Drug Delivery: Overview
701
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
701
Non-Oral Extravascular Drug Absorption Routes
460
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
460
Drug Delivery: Parenteral Route
1.4K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.4K
Drug Delivery: Enteral Route
1.5K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.5K
Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.5K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.5K

